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Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Sign of Leser-Trélat

This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.

Although most associated neoplasms are gastrointestinal [4] sigh stomachlivercolorectal and pancreasmalignancies of the breastlung[5] and urinary tract[6] as well as lymphoid tissue, have been associated with this impressive rash.


It is likely that various trelar and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. From Wikipedia, the free encyclopedia.

Andrews’ diseases of the skin: Article by Robert A Schwartz”. Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom.

Leser–Trélat sign – Wikipedia

Retrieved 15 July Beitrage zur Fruhdiagnose des Darmcarcinomas Hereditatsverhaltnisse und Hautveranderungen. The Oxford illustrated companion to medicine.

Oxford University Press US. Aldrich-Mees’ lines Beau’s lines Muehrcke’s lines Terry’s nails.

Eponymous medical signs for oncology. Russell bodies Auer rod Bence Jones protein. Granulocytosis Multicentric reticulohistiocytosis Nonbacterial thrombotic endocarditis.

Erythema gyratum repens Necrolytic migratory erythema. Febrile neutrophilic dermatosis Pyoderma gangrenosum Paraneoplastic pemphigus. Retrieved from ” https: Dermatologic signs Paraneoplastic syndromes. Views Read Edit View history.

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