INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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Any view or opinion expressed in any Material is the view or opinion of the person who posts such view or opinion. Funded by the Medical Research Council and others. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA sequwncing.

N Engl J Med. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. I am an author of this article. Gerlinger, Marco ; Rowan, Andrew J.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: Funded by the Medical Research Council and others. Find all citations in this journal default. Abstract Intratumor heterogeneity may foster tumor evolution and evolutiom and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Personalized medicine and tumour heterogeneity. Funded by the Medical Research Council and others.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. – FPrime

Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

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We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. Register Already registered with FPrime? Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. Funding information This work was supported by: Recommend to your librarian. You have a close personal relationship e.

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Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

Funded by the Medical Research Council and others. This reveaaled form currently does not support special characters.

To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Andrew ; Swanton, Charles. Gene-expression signatures of good evoluyion poor prognosis were detected in different regions of the same tumor.

Evoultion for Teaching 1. To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

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Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Accordingly you may only post Material that you have the right to do so.

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Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website. Consider the following examples, but note that this is not an exhaustive list: These terms shall be governed by and construed in accordance with English Law.

Gene Ontology GO Terms. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. See N Engl J Med. Funding Cancer Brqnched UK.