In cases of acute intoxication with propane butane (due to damage in heating appliances where propane-butane is used as energy source for heating), asphyxia. Butane is an organic compound with the formula C4H10 that is an alkane with four carbon . It enters the blood supply and within seconds produces intoxication. Butane is the most commonly misused volatile substance in the UK, and was the. Butane is a commonly misused volatile agent, and a cause of intoxication. We present a case, who had a syncope and persistent ventricular.
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Butane sniffing causing ventricular fibrillation; p. Database is relatively poor but the values are supported by the available animal data.
Two animal studies are available, a study with guinea intoxicaiton Nuckolls and a study with mice Stoughton and Lamson Intoxjcation, tissue concentrations of butane in rats were not determined after a 2-h exposure and the reported brain concentration could already have been reached with a shorter exposure duration. Case Reports Substance abuse is one of the predominant causes of death from butane intoxication.
Butane users should receive the same support as individuals using stimulants. A yearold girl, without history of butane abuse, had been inhaling butane intermittently over a period of 2 h. Shugaev determined LC 50 values for butane for 2-h exposures in mice and 4-h exposures in rats.
Data on butane Gill et al.
bugane The boy suffered from sinus tachycardia and a widespread ST-segment elevation was noted. During his hospitalization his cardiac status improved but brain functions remained disturbed Bauman et al.
Cardiac arrest following butane inhalation Sen A, Erdivanli B – Anesth Essays Res
No increase in the severity of response by duration is expected for concentration-dependent effects after reaching a steady state. It was concluded that the most plausible cause was a direct effect of butane on the myocardium. Other viscera were reported to be unremarkable. Light anesthesia was observed within 1 ay of exposure to butane atppm, and loss of posture was observed within 15 min.
Glutethimide Methyprylon Piperidione Pyrithyldione. Recovery was slow and complicated intoxicarion acute renal failure and recurrent pulmonary edema Edwards and Wenstone In an intermittent exposure test, subjects were exposed at fixed concentration for a short, unspecified duration.
Butane appears to be negative in the Ames test, with and without metabolic activation citation of an unpublished report in Moore Exposure groups consisted of laboratory or clerical personnel males and females, years of age. Edwards KE, Wenstone R. Although the intoxucation high will last only a few minutes, the effects can continue for up to 40 minutes.
Butane intoxication–three case reports.
Butane at concentrations ofandppm caused mortality see Section 3. Carr F, Prasad B. The increase to a quick equilibrium has been confirmed for propane, which has properties comparable to butane. Experiments with dogs Chenoweth ; Krantz et al. Sudden cardiac death and substance abuse; pp.
The animals were observed for h after exposure. Intoxicztion Six dogs were exposed to butane for various durations to study its potency as a cardiac sensitizer Chenoweth Gasoline-like or natural gas-like . Although it was not clearly described, the study description suggests that the animals were exposed under static conditions in a closed-chamber setting.
Butane – Drug and Alcohol Information and Support in Ireland –
Substance abuse is one of the predominant causes of death from butane intoxication. In another case of butane abuse, a swollen brain was observed in a year-old girl without a history of butane abuse Williams and Colewhile a CT head scan showed no abnormalities in a year-old male with a 3-year history of butane abuse Edwards and Wenstone Because human data are ingoxication, the AEGL-2 values are based on animal data.
Concentration-time mortality response relationship of irritant and systemically acting vapours and gases; pp.
The results of microbial mutation test for forty-three industrial chemicals; pp. A intoxicaton of data on lethality from acute inhalation of butane is provided in Table The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Groups of mice sex and strain not specified were exposed to butane at concentrations of , , , orppm; 6 mice were tested at the lowest concentration, and 10 mice at each of the higher concentrations Stoughton and Lamson No odor detection and no irritation were reported itoxication the continuous exposure test.
The authors subjected the individual animal data sets to probit analysis with exposure duration and exposure concentration as independent variables. Wikimedia Commons has media related to Butane. Retrieved 3 October