HEREDITARY GINGIVAL FIBROMATOSIS PDF

Hereditary gingival fibromatosis (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival overgrowth. HGF is characterized as a . Hereditary, drug-induced, and idiopathic gingival overgrowth have been reported . Hereditary gingival fibromatosis can occur as an isolated. Mutation in SOS1, son-of-sevenless gene, is thought to be responsible for hereditary gingival fibromatosis. This report shows a case of.

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Hereditary gingival fibromatosis

The HGF is classified in two types, nodular type and symmetric type. There are various procedures available for removal of HGF including surgery, electrocautery, and use of a carbon dioxide laser.

Miller M, Truhe T. Table of Contents Alerts.

There were no fluctuancy, no compressibility, no translucency, and no associated bleeding noted. However, the panoramic radiograph revealed normal bone height and tooth positioning. Received Sep 5; Accepted Hereditaty Hereditary gingival fibromatosis HGF is a rare condition with the prevalence of one fbromatosis population fibromatozis equal distribution in sexes [ 1 ]. Periodontal diseases in children and adolescents. Transforming growth factor-beta1 autocrine stimulation regulates fibroblast proliferation in hereditary gingival fibromatosis.

Syndromes of head and neck. For all other comments, please send your remarks via contact us. The pink, leathery consistency tissue was hard on palpation and covered complete crowns of the entire dentition. Miller M, Truhe T. Genetic linkage studies have found to localize genetic loci for autosomal dominant forms of HGF to chromosome 2pp22 indicative of HGF1 and chromosome 5qq22 indicative of HGF2.

Orphanet: Hereditary gingival fibromatosis

This article has been cited by other articles in PMC. It can cover teeth in various degrees, and can lead to aesthetic disfigurement. Intraoral view of mandibular arch showing a gross generalized growth of gingiva completely covering the mandibular teeth extending from right mandibular tuberosity to left tuberosity region.

SOURCE 1 In more recent scientific literature, there is evidence in which pedigree analyses confirm autosomal dominant, autosomal recessive or even as X-linked inherited cases fjbromatosis the HGF trait.

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HGF may be associated with other clinical manifestations such as hypertrichosis,[ 15 ] growth retardation,[ 16 ] hypopigmentation, mental deficiency,[ 17 ] epilepsy,[ 18 ] splenomegaly,[ 11 ] optic and auditory defects, cartilage and nail defects and dentigerous cysts.

Additional information Further information on this disease Classification s 2 Gene s 3 Clinical signs and symptoms Publications in PubMed Other website s 0. Am J Hum Gen.

The maxillary teeth were not all visible except in right and left posterior region. Excessive gingival growth results in pseudo pocketing and periodontal problems due to difficulties in daily oral hygiene.

Hereditary Gingival Fibromatosis: A Review and a Report of a Rare Case

In both cases it was found that on eliminating the gingival fibrosis, eruption proceeded physiologically. The underlying avascular stroma is almost entirely made up of dense collagen dibromatosis with only few fibroblasts. The surgical area was profusely irrigated with Betadine and normal saline. The patient’s jaw may also appear distorted because of the gingiva englargements.

Differential diagnosis gingivval oral gingivak in children. Adenosquamous carcinoma Basaloid squamous carcinoma Mucosal melanoma Spindle cell carcinoma Squamous cell carcinoma Verrucous carcinoma Oral florid papillomatosis Oral melanosis Smoker’s melanosis Pemphigoid Benign mucous membrane Pemphigus Plasmoacanthoma Stomatitis Aphthous Denture-related Herpetic Smokeless tobacco keratosis Submucous fibrosis Ulceration Riga—Fede disease Verruca vulgaris Verruciform xanthoma White sponge nevus.

Radiography showed appropriate root development, with two thirds of the root formed Fig. Regarding the higher rate of recurrence in children and teenagers compared to adults [ 18 ], we found it better to delay surgical intervention gingivectomy until commencement of the presurgical orthodontic phase and planned periodic visits to monitor eruption of remained permanent teeth.

The symmetric form, which is the most common type of disorder, results in uniform enlargement of the gingiva that is firm, dense, resilient, insensitive fibrous tissue that covers the alveolar ridges and extends over the teeth resulting in extensive pseudo pockets.

Case of gingivomatosis or elephantiasis of gingival. Post-surgical healing was uneventful. The histological evaluation of the section revealed moderately dense to ginyival dense collagenous connective tissue with collagen bundles arranged in haphazard manner. Hereditary gingival fibromatosis HGF is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent or more rarely the primary dentition or even at birth.

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The patient noted the growth 3 years back, since then it was progressively increasing in size causing inadequate lip apposition and poor esthetic. Her parents did not reveal any evidence of gingival overgrowth. The surface was smooth and lobulated. Juvenile hyaline fibromatosis Murray-Puretic Drescher Syndrome: As stated earlier both autosomal dominant and recessive modes of transmission of HGF have been reported [ 3 — 5 ]. An occurrence of the disease has been found in two generations of this family and therefore, it may be following autosomal dominant trait of inheritance.

It was explained for the parents that the long face growth pattern is hard to modify and the treatment must continue over many years which needs excellent cooperation [ 7 ].

It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. SOURCE 2 In some cases, there is re-growth after surgical removal of the excess gingival tissues, in others there is minimal. Diagnoses Chronic periodontitis Localized aggressive periodontitis Generalized aggressive periodontitis Periodontitis as a manifestation of systemic disease Periodontosis Necrotizing periodontal diseases Abscesses of the periodontium Combined periodontic-endodontic lesions.

Evidence of genetic heterogeneity for hereditary gingival fibromatosis. Genetic linkage studies are among the most popular methods of study to look at the mechanism of this HGF.

There is an insertion of a cytosine between nucleotidesandin codon of the SOS1 gene, meaning there is a mutation in SOS1. The CO 2 laser in oral and maxillofacial surgery. The gingival enlargement may occur alone or in combination of other symptoms as part of a syndrome. Clinically unaffected individuals are indicated by an unblackened symbol. Severe hperplasia can result in restricted movements of the tongue, speech impediments, difficulty with mastication, and can prevent normal closure of lips.

Case Reports -Case 1.