Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.
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Published online Feb The fibers in the papillary layer are thickened, arranged vertically and penetrate into the skin, where they form characteristic narrow tunnels with a right, wave or spiral arrangement.
Though numerous treatment modalities have been described in the literature, most are not very effective. Medical College and B. Penicillamine-induced elastosis perforans serpiginosa with abnormal “lumpy-bumpy” elastic fibers in lesional and non-lesional skin.
What is standard of care in the evaluation of elastosis perforans serpiginosa? Partially the parakeratotic keratin plug contains an addition of basophilic masses and elastosi nuclei of inflammatory cells. Received Jan 15; Accepted Feb Treatment of elastosis perforans serpiginosa with the flashlamp pulsed dye laser.
You can help Wikipedia by expanding it. The lesions tend to subside in the center and often solitary satellite lesions in the close vicinity are detected. In the latter case, the treatment has pegforans been undertaken [ 6 ]. Penicillamine-induced pseudoxanthoma elasticum with elastosis perforans serpiginosa: Brown, MD ; Jeffrey P. In addition to a marked increase in the amount and thickness of papillary pefforans elastic tissue, a chronic inflammatory infiltrate containing lymphocytes, macrophages, or multinucleated giant cells may be present in the dermis at the sites of perforation.
Elastosis perforans serpiginosa and associated disorders.
Laser treatment, including carbon dioxide laser and Er: The patient was treated unsuccessfully with cryotherapy approximately 6 times; high-potency topical corticosteroids, including clobetasol and halobetasol, for 6 weeks; topical 0. Chilblain Lupus erythematosus—lichen planus overlap syndrome Tumid Verrucous Rowell’s syndrome.
Elastosis perforans serpiginosa: a review of the literature and our own experience
The diagnosis of elastosis perforans serpiginosa is made by its clinical appearance and by the characteristic histology changes seen on skin biopsyshowing transepidermal elimination of elastic tissue.
The pinhole method using a carbon dioxide laser showed complete clearing without post-treatment scarring Lever’s histopathology of the skin. This cutaneous condition article is a stub. Lippincott Williams and Wilkins; Histopathologic picture of EPS with thick epidermis and transepidermal channel A—Chorny plug A, C and mixed inflammatory infiltration within the dermis B.
Open in a separate window. Elastosis perforans serpiginosa EPS is a rare disorder classified as a primary perforating dermatosis. Fitzpatrick’s Dermatology in General Medicine. The “lumpy-bumpy” elastic fiber.
Familial cases of EPS have also been reported, with the mode of inheritance suggested to be autosomal dominant with variable trait expressivity 67.
Elastosis perforans serpiginosa is a unique perforating disorder characterized by transepidermal elimination of elastic fibers and distinctive clinical lesionswhich are serpiginous in distribution and can be associated with specific diseases. Am J Dermatopathol ;3: Histopathology of the Skin. The diagnosis of EPS should not be based solely on the dermatological examination and evaluation of EPS-specific skin lesions, but rather on the histological assessment of biopsy of the affected skin [ 1 ].
Long term D-penicillamine therapy causes an alteration in the dermal elastic tissue. InMiescher showed that the extruded material contains elastin and suggested the term elastomer intrapapillare perforans veruciformewhich inDammert and Putkonem changed into EPS [ 12 ].
A marker of long-term administration of penicillamine. The last subtype, idiopathic one, may be associated with genetic basis of the autosomal dominant type of inheritance.
Tazarotene Is an Effective Therapy for Elastosis Perforans Serpiginosa
After obtaining the result of the histopathological examination, the nature of perfprans disease, possibilities as well as the effectiveness and purpose of the serpiginosq were explained to the parents. However, others, like Saxena did not show a positive response to numerous sessions using these lasers, and in turn, CO 2 laser caused scarring [ 16 ]. It looked like entering the canals toward the outside of the skin Fig. Keratoderma climactericum Paraneoplastic keratoderma Acrokeratosis paraneoplastica of Bazex Aquagenic keratoderma Drug-induced keratoderma psoriasis Keratoderma blennorrhagicum keratosis: