Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

Author: Goltir Kagajin
Country: Germany
Language: English (Spanish)
Genre: Automotive
Published (Last): 21 July 2010
Pages: 346
PDF File Size: 12.23 Mb
ePub File Size: 1.82 Mb
ISBN: 775-4-90191-460-8
Downloads: 70531
Price: Free* [*Free Regsitration Required]
Uploader: Tygolrajas

Lodotra TM has been designed so that maximum plasma levels are reached six hours after intake.

Recent technologies in pulsatile drug delivery systems

Now-a-days, the emphasis of pharmaceutical researchers is turned towards the development of more efficacious drug delivery systems with already existing molecule. Proton pump inhibitors Neurological disorders The central pathophysiology of epilepsy and the behavioral classification of convulsive events. As the pulsatile drug delivery achieve desired therapeutic effect and reducing side effect, so patient compliance can be obtained along with lowering dose frequency.

Thickness of the coating decides the lag time. This flexibility simplifies dose-ranging studies for drug development partners involved in clinical testing, because the beads can be encapsulated separately to create separate study arms. Development of dividable one-step dry-coated tablets dividable-OSDRC and their evaluation as a new platform for controlled drug release.

The whole unit is coated with an enteric polymer to avoid the problem of variable gastric emptying.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

Pulsatile drug delivery system. The drug is forced out of the particle into the exterior through the coating. In this technology, a bilayer tablet was manufactured. This deviation technklogy normal range acts as a stimulus that triggers the release of therapeutic agents from several temperature-responsive drug delivery systems. Such a release pattern is known as pulsatile release. Hydration of the osmotic engine leads to its expansion, which exerts a driving force against the ridge of the drug vessel.


A magnetically triggered composite membrane for on-demand drug delivery. The controlled-onset delivery system results in a maximum plasma concentration C max of verapamil in the morning hours. The drug can be combined in two ways, one with the neutral core second incorporated into the coating process Drug release from intelligent gels responding to antibody concentration In the human body numerous kinds of bioactive compounds are exist.

Multiparticulate Drug Delivery System. Externally Regulated System Magnetic induces release Magnetically regulated system contains magnetic beads in the implant.

The inflamed responsive cells produce hydroxyl radicals. Capsule Shaped Pulsatile Drug Delivery System This dosage form consists of an insoluble capsule body containing drug and a release controlling plug Soluble is fitted between immediate release compartment and pulsed release compartment Figure.

This is a site-specific and time-dependent formulation; texhnology. Formulation and stastical ttechnology of time controlled pulsatile release propranolol hydrochloride compressed coated tablet.

Prior to coating with one or more polymers, a neutral core is coated with a drug substance to achieve a once-a day release profile. This proprietary technology has been developed specifically for ttechnology, basic drugs and involves the incorporation of a pharmaceutically acceptable organic acid or a crystallization-inhibiting polymer onto inert cores and coating the drug-layered beads with proprietary functional polymers.

Great interest is taken in site and time specific oral drug delivery to improve therapeutic efficacy. Degradation of HA via the hyaluronidase is very low in a normal state of health.

Sharma S and Pawar A: Related article at PubmedScholar Google. The release controlling coating is a blend of water soluble and water insoluble polymers. Reports in the literature have highlighted the many advantages of the diffuxaps system over other processes in enhancing pharmaceutical applications; these include new methods in design, development, manufacture and commercialization of various types of solid dosage forms.

Bussemer T, Bodmeier R. Chronotropic system consists of a core containing drug reservoir coated by duffucaps hydrophilic polymer HPMC. Formulation and evaluation of pulsatile drug delivery system for chronobiological disorder: Pulsatile drug delivery systems can be classified in to three categories:.


Formulation and evaluation of floating pulsatile Multiparticulate using pH dependent swellable polymers.

Ritschel WA, Forusz H. Additional membranes may be added to further control release rate. Microchips as controlled drug-delivery devices.

Recent technologies in pulsatile drug delivery systems

Antigenantibody complex formation is of great importance as the cross-linking units in the gel due to such specific interaction.

Internally stimuli induced system Temperature—induced pulsatile release: The system is comprised of a water insoluble capsule enclosing the drug reservoir. Timing drug availability with therapeutic need. The objective was to develop a once-daily controlled release system with a fast onset of action and reduced gastric irritancy.

Pulsatile drug delivery systems PDDS have attracted attraction because of their multiple benefits over conventional dosage forms.

This technology techjology on osmotic pressure to give pre-programmed, controlled drug delivery to the gastrointestinal tract. Can’t read the image? Magnetic modulation of release of rechnology from polymers. The beads contain a layer of organic acid or alkaline buffer to control the solubility of a drug by creating an optimal pH microenvironment for drugs that exhibit poor technoloogy in intestinal pH, in environments with pH greater than 8. Chemical stimuli induced pulsatile release: The fiffucaps time increases with increasing coating thickness and hardness of the core table.

Another formulation approach was in the form of a bead or granule with a four-layered spherical structure, which consists of a core, a drug, swelling agent e.

There are numerous advantages of the pulsatile drug delivery systems.