Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.
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Factor de coagulación XI – Wikipedia, la enciclopedia libre
The results showed other algae with slightly inhibition of clot formation activity, it is not common to consider this species for further investigation, nevertheless the retardation of formation of clot by Penicillus capitatusa species evolutionary related to Halimeda genus Vroom et al. The New England Journal of Medicine 3: The Journal of Biological Chemistry Agardh Rhodophyta retarded the coagulation process of human plasma in both anticoagulant tests for less than two minutes period and more than one minute.
Niveles elevados de factor XI han sido implicados en casos de trombosisaunque es incierto que es lo que determina estos niveles, y cuan severo puede ser el estado procoagulante. Purification and characterization of two fibrinolytic enzymes from the marine green alga, Codium eztrinseca.
coagulación – English Translation – Word Magic Spanish-English Dictionary
De Wikipedia, la enciclopedia libre. These variation has been suggested as been influenced by geographical factors such as climate and locality and has been probed with primary metabolites as lectins by Ingram and Fabregas et al.
Pharmacological activities of marine algae. British Journal of Haematology 90 4: American Journal of Clinical Pathology A fibrinolytic enzyme from a marine green alga, Codium latum. Studies on anticoagulant-active arabinan sulfates form the green alga, Codium latum. We can concluded that some substances present in the algal extract can act on any of the enzyme or substrate inhibiting the transformation of prothrombin to etxrinseca or in the activation process of fibrinogen to coagulacuon.
As anticoagulant time reference 6.
We considered that extracts who acted on both path-ways of clot formation, affect the cascade of coagulation in the point of convergence, that is in transformation of fibrinogen to fibrin.
A total of five species were active in standard clotting test, three of Intrinsecaa, one from Phaeophyta and one from Rhodophyta.
In Campeche state we colleted phycological material cascaa Journal Biological Chemistry Supporting the use of this method is the evidence that the results of Deacon et al. En humanos, el factor XI se encuentra codificado por el gen F This is the first report of anticoagulant activity in Anadyomene stellataLobophora variegata and Liagora farinosa. Journal of Applied Phycology We collected algal material along the central coast of Veracruz, and some localities of Campeche, Yucatan and Cascadda Roo States in order to have samples of the coast of the Atlantic Ocean in Mexico Gulf of Mexico and Caribbean sea.
An anticoagulant proteoglycan from the marine green alga, Codium pugni-formis.
Consultado el 7 de abril de Developments in Comparative Immunology 9: These molecules have different degree of sulfate in their structure coagulzcion therefore are capable of substitute heparin Farias et al.
Se concluye que estas especies pueden ser consideradas como una fuente alternativa de nuevos anticoagulantes. The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Mexican Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2. Rhamnan sulfate from cell walls of Monostroma latissimum.
Nucleic Acids Research 19 The results showed that four species presented potent anticoagulant activity same as cascafa in the two pathways: Heparin, a sulphated glycosaminoglycan wide used in oral anticoagulant therapy, was used as reference in both proofs.
It is relevant to point out the dependence of anticoagulant potency due to the locality where algae grows, also the date of collection and thus, the climate season is other factor that could influence the synthesis of compounds, particularly in the brown alga Lobophora variegata we observed the double anticoagulant action in sample collected in May ofbut six months later Novembersame specie only was active in the prothrombin time test.
Factor de coagulación XI
On the quantitative estimation of prothrombin. Structure of a fucose-branched chondroitin sulfate from sea cucumber. Cytogenetics and Cell Genetics 52 We also detected a variation in the anticoagulant potency, a change in the anticoagulant activity related with the intrinsic or extrinsic pathways of coagulation or even the disappearance of the anticoagulant activity in both test of Caulerpa cupressoidesC.
Agardh, Caulerpa cupressoides West in Vahl C. British Phycological Journal Similar results of slightly anticoagulant potency were observed but in thrombin time test for C. Occurrence of heparin in the invertebrate Styela plicata Tunicata is restricted to cell layers facing the outside environment.
Forty nine seaweed species collected off shore of several localities of Gulf of Mexico and Mexican Caribbean sea were screened in order to detect anticoagulant activity in both intrinsic and extrinsic pathways of clot formation. Thrombosis Research 55 3: One of the extracts of C. The research effort has been focused on one genus, forgotten the basic detection of different algae as a potential source of alternative anticoagulant molecules.
The extracts could act preventing the conversion of prothrombin to thrombin, also they could act stopping the transformation of fibrinogen to convert it to fibrin o even in the polymerization of this last molecule. Cryptogamie Dee 16 3: In the laboratory the material was thawed at room temperature and a fraction of this was preserved in glycerinated formaldehyde for species determination and Voucher organisms, this specimens were kept in our laboratory as internal reference material.
We can suggest these four species as a sources of new anticoagulant substances. A simple method of studying the generation of thrombin in recalcificated plasma.