British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.
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It was believed to have much greater toxicity than mustard gas, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky Keep Exploring Britannica Television.
From Wikipedia, the free encyclopedia. Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare. During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent.
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Pharmacy and pharmacology portal Medicine portal. BAL is not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Blanusa et al ; Archer InBrigish found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter We welcome suggested improvements to any of our articles.
However, it is not necessarily the treatment bitish choice for toxicity to these metals. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in britjsh of cadmium toxicity is to be avoided. By the end of World War IIdimercaprol had also been found useful as an antidote against poisoning by several metals and semimetals—including arsenicgoldleadand mercury—that act by combining with cellular sulfhydryl groups.
Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal. British anti-Lewisite was developed in as an antidote to lewisite, an arsenic-based chemical warfare agent.
Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb Nonetheless, because it can have serious adverse effectsresearchers have also pursued development of less toxic analogues. Human and Experimental Toxicology Please try again later. Retrieved 22 April Common side effects include high blood pressurepain at the site of the injection, vomiting, and fever.
Other agents have been developed since Brewer Learn More in these related Britannica articles: Your contribution may be further edited by our staff, and its publication is subject to our final approval.
In other projects Wikimedia Commons. Retrieved from ” https: Parenteral British anti-Lewisite can be successfully used in lead poisoning if oral therapy fails.
It has been postulated that, because BAL is nonpolar, it may accelerate the removal of copper from within the oewisite compared to more modern agents Scheimberg and Sternlieb ; Walshe You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind. Archived PDF from the original on 23 April Thank You for Your Contribution!
Skeletal formula and ball and stick model of dimercaprol. By32 articles had been published or were in press on the therapeutic value of BAL Ord Other drawbacks include the need to administer it by painful intramuscular injection.
The Royal Society of Chemistry.
British anti-Lewisite is occasionally used for both acute heavy metal intoxication nritish Wilson disease. Lewisite 2-chlorovinyldichoroarsine is an arsenic-based vesicant chemical warfare agent that was initially developed, although not used, by the United States during World War I.
C Risk not ruled out. Arsenic poisoning Dimercaprol Succimer. You may find it helpful to search within brritish site to see how similar or related subjects are covered. Automobile, a usually four-wheeled vehicle designed primarily for passenger transportation and commonly…. International journal of immunopathology and pharmacology. There was a problem with your submission.
More About Dimercaprol 1 reference found in Britannica articles Assorted References arsenic poisoning In arsenic poisoning. In This Article Introduction.
Ajti compound is useful for the treatment of potentially life-threatening acute arsenic poisoning as well. If you prefer to suggest your own revision of the article, you can go to edit mode requires login. Eagle and Magnuson found that 48 patients with severe or mild symptoms of arsenical encephalopathy were effectively treated with BAL Eagle and Magnuson Internet URLs are the best.
This drug is not indicated in patients with iron, cadmium, selenium, silver, or uranium poisoning.
British anti-Lewisite Molecule of the Month – May
If you are a subscriber, please log in. Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson’s disease. Archived from the original on 21 December