British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.
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Dimercaprol – Wikipedia
Your contribution may lewissite further edited by our staff, and its publication is subject to our final approval. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided. In other projects Wikimedia Commons. However, it is not necessarily the treatment of choice for toxicity to these metals.
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It was believed to have much greater toxicity than mustard gas, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky The content you are trying to view is available only to logged in, current MedLink Neurology subscribers.
British anti-Lewisite is occasionally used for both acute heavy metal intoxication and Wilson disease. Archived PDF from the original on 23 April Rev Environ Contam Toxicol Discover some of the most interesting and trending topics of Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand nickel.
Nonetheless, because it can have serious adverse effectsresearchers have also pursued development of less toxic analogues.
Human and Experimental Toxicology The Royal Society of Chemistry. You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind. It is a potentially toxic drug, and its use may be accompanied by multiple side effects.
Please try again later. Other agents have been developed since Brewer If you prefer to suggest your own revision of the article, you can go to edit mode requires antl.
British anti-Lewisite Molecule of the Month – May
Pharmacy and pharmacology portal Medicine portal. Arsenic poisoning Dimercaprol Succimer. Dimercaprol Skeletal formula and ball and stick model of dimercaprol. If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services.
Dimercaprolalso called British anti-Lewisite BALis a medication used to treat acute poisoning by arsenicmercurygoldand lead. Automobile, a usually lewisitd vehicle designed primarily for passenger transportation and commonly…. Keep Exploring Britannica Television.
By32 articles had been published or were in press on the therapeutic value of BAL Ord C Risk not ruled out. Archived PDF from the original on 13 December BAL lewidite not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Lfwisite et al ; Archer Plans for the possible production ofpounds per year were developed Waters and Stock Site license users, click the Site License Acces link on the Homepage at an authorized computer.
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Retrieved 22 April Please note that our editors may make some formatting changes or correct spelling or grammatical errors, and may also contact you if any clarifications are needed.
The Editors of Encyclopaedia Britannica. There was a problem with your submission. Experimental observations revealed that dimercaprol may be an effective neuroprotective agent.
Dimercaprol also enhances the toxicity of selenium and telluriumso it is not to be used to remove these elements from the brutish. InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter